Semaglutide Reconstitution Calculator & Dosing Guide
Exact syringe markings for every standard semaglutide dose, full titration schedule, and handling guidance for compounded vials. Designed for the telehealth semaglutide era.
Open the Calculator Pre-Loaded for Semaglutide
Pick your vial size and dose — get exact syringe markings instantly.
Open Calculator →What Is Semaglutide?
Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist developed by Novo Nordisk. It slows gastric emptying, promotes satiety, and stimulates insulin secretion in a glucose-dependent manner. The FDA has approved it under three brand names: Ozempic (type 2 diabetes, 2017), Wegovy (chronic weight management, 2021), and Rybelsus (oral form for diabetes, 2019).
Compounded semaglutide is dispensed as a lyophilized powder by 503A and 503B pharmacies through telehealth providers. It requires reconstitution with bacteriostatic water before the first dose. The active molecule is the same as the brand products, but regulatory status and inactive ingredients differ.
Common Reconstitution Ratios
| Vial size | BAC water | Concentration | 0.25 mg draw (U100) | 1 mg draw (U100) | 2.4 mg draw (U100) |
|---|---|---|---|---|---|
| 2 mg | 1 ml | 2 mg/ml | 12.5 units | 50 units | exceeds 1ml |
| 5 mg | 2 ml | 2.5 mg/ml | 10 units | 40 units | 96 units |
| 5 mg | 1 ml | 5 mg/ml | 5 units | 20 units | 48 units |
| 10 mg | 2 ml | 5 mg/ml | 5 units | 20 units | 48 units |
| 10 mg | 1 ml | 10 mg/ml | 2.5 units | 10 units | 24 units |
For the weight-management titration (0.25 → 2.4 mg), a 5 mg vial + 2 ml BAC water (2.5 mg/ml) fits every dose on a single 100-unit U100 syringe draw. This is the most common compounded semaglutide setup.
Semaglutide Titration Schedule
Novo Nordisk's approved Wegovy titration (weight management):
| Month | Weekly dose | Purpose |
|---|---|---|
| 1 | 0.25 mg | Starting / tolerance phase |
| 2 | 0.5 mg | Step-up |
| 3 | 1 mg | Therapeutic range begins |
| 4 | 1.7 mg | Step-up |
| 5+ | 2.4 mg | Maintenance (target for weight loss) |
For Ozempic (diabetes), the approved titration stops at 1 or 2 mg — titration schedule is similar up to that ceiling. Microdosing (staying at 0.25 or 0.5 mg) is increasingly popular among users aiming for minimal side effects.
Storage and Handling
- Pre-reconstitution: Freezer-stable long term; room-temp OK for shipping.
- Post-reconstitution: Refrigerate at 36–46°F. Stable ~28 days.
- No freeze-thaw cycles — each cycle degrades semaglutide.
- Protect from light — use amber vials or store in a dark container.
- Discard if cloudy, discolored, or particulates appear.
Frequently Asked Questions
How do I reconstitute compounded semaglutide?
Most commonly: 5 mg vial + 2 ml BAC water = 2.5 mg/ml, which fits every dose from 0.25 to 2.4 mg in a single U100 syringe draw. Adjust based on your vial size using the calculator.
What is the standard semaglutide titration schedule?
0.25 mg week 1-4, 0.5 mg week 5-8, then optional 1.0, 1.7, and 2.4 mg, each for at least 4 weeks. Wegovy targets 2.4 mg; Ozempic maxes at 1-2 mg.
How long does reconstituted semaglutide last?
~28 days refrigerated. Discard if cloudy, discolored, or past 28 days.
Is compounded semaglutide the same as Ozempic or Wegovy?
Same active molecule. Brand products ship as prefilled pens with FDA-approved labeling. Compounded semaglutide is a lyophilized vial from 503A pharmacies, requiring reconstitution. Legality of compounded semaglutide depends on FDA shortage status and your jurisdiction.
Can I microdose semaglutide?
Many users stay at 0.25 or 0.5 mg indefinitely to minimize side effects while still benefiting from appetite suppression. This isn't the manufacturer protocol but is increasingly common in telehealth practice. Discuss with your prescriber.
Where do I inject semaglutide?
Subcutaneous: abdomen (2 inches from navel), upper outer thigh, or back of upper arm. Rotate sites weekly. Stackr tracks injection site rotation automatically.
Track Your Semaglutide Protocol in Stackr
Weekly dose logging, titration tracking, side effect journal, injection site rotation, and reorder alerts.
Download Stackr Free →Related Calculators
Stackr is a personal supply and protocol tracking tool. Nothing on this page is medical advice. Always consult a qualified healthcare professional before starting, changing, or stopping any medication. Compounded semaglutide legality and availability vary by jurisdiction and change over time based on FDA shortage determinations.